Research | Funded Projects

MODULATORI SMALL-MOLECULE DELL'ATTIVITÀ BIOLOGICA DI P53: NUOVI TOOL PER LA CHIMICA FARMACEUTICA MITOCONDRIALE

1) Claudia Colussi, Jessica Rosati, Stefania Straino, Francesco Spallotta, Roberta Berni, Donatella Stilli, Stefano Rossi, Ezio Musso, Emilio Macchi, Antonello Mai, Gianluca Sbardella, Sabrina Castellano, Cristina Chimenti, Andrea Frustaci, Angela Nebbioso, Lucia Altucci, Maurizio C. Capogrossi, Carlo Gaetano, Nε-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart Proc Natl Acad Sci U S A. 2011, 108, 2795–2800. IF: 9,74 FC: 1 Tot: 9,7372) Gianluca Sbardella*, Antonello Mai, Sara Bartolini, Sabrina Castellano, Roberto Cirilli, Dante Rotili, Ciro Milite, Marisabella Santoriello, Serena Orlando, Ilaria Sciamanna, Annalucia Serafino, Patrizia Lavia, and Corrado Spadafora, Modulation of Cell Differentiation, Proliferation and Tumor Growth by Dihydrobenzyloxopyrimidine Non Nucleoside Reverse Transcriptase InhibitorsJ. Med. Chem. 2011, 54, 5927–5936. IF: 5,61 FC: 1,5 Tot: 8,4213) Sabrina Castellano, Dirk Kuck, Monica Viviano, Jakyung Yoo, Fabian López-Vallejo, Paola Conti, Lucia Tamborini, Andrea Pinto, Jose Luis Medina-Franco, and Gianluca Sbardella*, Synthesis and Biochemical Evaluation of D2-Isoxazoline Derivatives as DNA Methyltransferase 1 InhibitorsJ. Med. Chem. 2011, 54, 7663–7677. IF: 5,61 FC: 1,5 Tot: 8,4214) Sabrina Castellano, Sabrina Taliani, Ciro Milite, Isabella Pugliesi, Eleonora Da Pozzo, Elisa Rizzetto, Sara Bendinelli, Barbara Costa, Sandro Cosconati, Giovanni Greco, Ettore Novellino, Gianluca Sbardella, Giorgio Stefancich, Claudia Martini, and Federico Da Settimo, Synthesis and Biological Evaluation of 4-Phenylquinazoline-2-carboxamides Designed as a Novel Class of Potent Ligands of the Translocator Protein J. Med. Chem. 2012, 55, 4506–4510. IF: 5,61 FC: 1,5 Tot: 8,4215) Sabrina Castellano, Astrid Spannhoff, Ciro Milite, Fabrizio Dal Piaz, Donghang Cheng, Alessandra Tosco, Monica Viviano, Abdellah Yamani, Agostino Cianciulli, Marina Sala, Vincent Cura, Jean Cavarelli, Ettore Novellino, Antonello Mai, Mark T. Bedford, and Gianluca Sbardella*, Identification of Small-Molecule Enhancers of Arginine Methylation Catalyzed by Coactivator-Associated Arginine Methyltransferase 1J. Med. Chem. 2012, 55, 9875–9890. IF: 5,61 FC: 1,5 Tot: 8,4216) Elena Calabrese, Sabrina Castellano*, Marisabella Santoriello, Cristina Sgherri, Mike Quartacci, Lucia Calucci, Andrew Warrilow, David Lamb, Steve Kelly, Ciro Milite, Ilaria Granata, Gianluca Sbardella, Giorgio Stefancich, Bruno Maresca, Amalia Porta., Antifungal Activity of Azole Compounds CPA18 and CPA109 against Azole-Susceptible and -Resistant Strains of Candida albicansJ. Antimicrob. Chemother. 2013, 68, 1111–1119. IF: 5,34 FC: 1,5 Tot: 8,0077) Astrid Spannhoff, Yong Kee Kim, Noel J -M Raynal, Vazganush Gharibyan, Ming-Bo Su, Yue-Yang Zhou, Jia Li, Sabrina Castellano, Gianluca Sbardella, Jean-Pierre J Issa, Mark T Bedford, Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees EMBO rep. 2011, 12, 238–243. IF: 7,19 FC: 1 Tot: 7,1898) Ortuso, F., Paduano, F., Carotenuto, A., Gomez-Monterrey, I., Bilotta, A., Gaudio, E., Sala, M., Artese, A., Vernieri, E., Dattilo, V., Iuliano, R., Brancaccio, D., Bertamino, A., Musella, S., Alcaro, S., Grieco, P., Perrotti, N., Croce, C.M., Novellino, E., Fusco, A., Campiglia, P*., Trapasso, F. Discovery of PTPRJ agonist peptides that effectively inhibit in vitro cancer cell proliferation and tube formationACS Chemical Biology, 2013, 8, 1497-1506. IF: 5,44 FC: 1,5 Tot: 8,1639) A. Bertamino, M. Soprano, S. Musella, M.R. Rusciano, M. Sala, E. Vernieri, V. Di Sarno, A. Limatola, A. Carotenuto, S. Cosconati, P. Grieco, E. Novellino, M. Illario, P. Campiglia, I. Gomez-Monterrey, Synthesis, in vitro, and in cell studies of a new series of [Indoline-3,2′-thiazolidine]-based p53 modulatorsJournal of Medicinal Chemistry, 2013, 56, 5407-5421. IF: 5,61 FC: 1,5 Tot: 8,421