Department | Life science laboratories

Activities

“Life science instrumentation laboratories” provide a technological platform for rapid screening of vast libraries of chemical compounds, supporting the scientific activities of university researchers working in the life sciences. In such laboratories, experiments aimed at studying the interaction of potential bioactive molecules with molecular targets involved in the onset and/or progression of specific diseases are conducted. Through the use of state-of-the-art technologies, and thus instrumentation present in that laboratory, it is possible to obtain kinetic and thermodynamic information on the ligand-receptor interaction thus accelerating the drug discovery process.

Equipment

“Life science instrumentation laboratories” are equipped with state-of-the-art instrumentation in order to ensure an advanced research experience. The equipment includes:

No.3 Surface Plasmon Resonance (SPR) systems:

• Biacore™ T200 (Cytiva, Sweden)

• Biacore 3000 (Cytiva, Sweden)

• Biacore 2000 (GE Healthcare, Sweden)

No.1 Nano-Differential Scanning Fluorimetry (nanoDSF) Analysis System:

• Prometheus NT.48 (Nanotemper, Germany)

No.2 MicroScale Thermophoresis (MST) Systems.

• Monolith NT.115Pico (Nanotemper, Germany)

• Monolith NT.Automated (Nanotemper, Germany)

No.1 Isothermal Titration Calorimetry (ITC) Analysis System:

• MicroCal iTC200 (Malvern)

No.1 System for real-time enzyme kinetics assays:

• LabChip® EZ Reader (PerkinElmer, USA)

No.3 Multimodal plate readers.

• EnSpire Alpha Plate Reader (PerkinElmer, USA)

• EnSpire Multimode Plate Reader, without ALPHA module (PerkinElmer, USA)

• EnSight Multimode Plate Reader (PerkinElmer, USA)

No.1 Automated Dispenser

• Janus Automated Liquid Handling Workstation (PerkinElmer, USA)