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The present invention relates to e class of novel compounds wich can be used as potassium ion channels modulators, the preparation methods thereof and the use of these compounds, or their pharmaceutically acceptable salts, or their pharmaceutical compositions in the preparations of medicaments for the treatment of central or peripheral nervous sistem diseasis and /or respiratory sistem diseasis and/or genitourinari sistem diseasis and /or gastrointestinal sistem diseasis and/or cardiovascular diseasis.